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fastmover
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Next time we are back, an introduction of pook to my girl is in order. Sorry we missed an introduction last visit.
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Thai Girls : Meet Sexy Thai Girls
Posted on: 11:03 pm on April 23, 2004
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ringthebells
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for sure.
but what will we do?? watch, join and drink whisky??
ok.
rtb
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Bangkok Women : Meet Sensual Bangkok Women
Posted on: 11:18 pm on April 23, 2004
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fastmover
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You will drink the whiskey, I will drink the view.
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Thai Girls : Meet Sexy Thai Girls
Posted on: 12:10 am on April 24, 2004
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layne_staley
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The Thai govt is paying anyone $75k of they catch SARS in Thailand, or so I read.
I may just go searching for it.
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Bangkok Girls : Meet Sexy Bangkok Girls
Posted on: 6:43 am on April 24, 2004
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poskat
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The danger of SARS is reduced in Western/Causasians. The morbidity associated with SARS has to do with the body's immune response to the viral infection, not the infection itself per se. Current treatment revolves around reducing the immune response. It was found that Asians have 2 genetic variations associated with white blood cell function that is not present in Western individuals. You may recall there were few deaths of Westerners, but many of Asians in Toronto. Also, no deaths in the US despite some cases. I'll look for the reference on this and post when I find it.
poskat
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Thai Women : Meet Matured Thai Women
Posted on: 10:22 am on April 24, 2004
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poskat
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Association of HLA class I with severe acute respiratory syndrome coronavirus infection.
Lin M, Tseng HK, Trejaut JA, Lee HL, Loo JH, Chu CC, Chen PJ, Su YW, Lim KH, Tsai ZU, Lin RY, Lin RS, Huang CH.
Office of Director, Mackay Memorial Hospital, Taipei, Taiwan. chhuang@ms2.mmh.org.tw
BACKGROUND: The human leukocyte antigen (HLA) system is widely used as a strategy in the search for the etiology of infectious diseases and autoimmune disorders. During the Taiwan epidemic of severe acute respiratory syndrome (SARS), many health care workers were infected. In an effort to establish a screening program for high risk personal, the distribution of HLA class I and II alleles in case and control groups was examined for the presence of an association to a genetic susceptibly or resistance to SARS coronavirus infection. METHODS: HLA-class I and II allele typing by PCR-SSOP was performed on 37 cases of probable SARS, 28 fever patients excluded later as probable SARS, and 101 non-infected health care workers who were exposed or possibly exposed to SARS coronavirus. An additional control set of 190 normal healthy unrelated Taiwanese was also used in the analysis. RESULTS: Woolf and Haldane Odds ratio (OR) and corrected P-value (Pc) obtained from two tails Fisher exact test were used to show susceptibility of HLA class I or class II alleles with coronavirus infection. At first, when analyzing infected SARS patients and high risk health care workers groups, HLA-B*4601 (OR = 2.08, P = 0.04, Pc = n.s.) and HLA-B*5401 (OR = 5.44, P = 0.02, Pc = n.s.) appeared as the most probable elements that may be favoring SARS coronavirus infection. After selecting only a "severe cases" patient group from the infected "probable SARS" patient group and comparing them with the high risk health care workers group, the severity of SARS was shown to be significantly associated with HLA-B*4601 (P = 0.0008 or Pc = 0.0279). CONCLUSIONS: Densely populated regions with genetically related southern Asian populations appear to be more affected by the spreading of SARS infection. Up until recently, no probable SARS patients were reported among Taiwan indigenous peoples who are genetically distinct from the Taiwanese general population, have no HLA-B* 4601 and have high frequency of HLA-B* 1301. While increase of HLA-B* 4601 allele frequency was observed in the "Probable SARS infected" patient group, a further significant increase of the allele was seen in the "Severe cases" patient group. These results appeared to indicate association of HLA-B* 4601 with the severity of SARS infection in Asian populations. Independent studies are needed to test these results.
Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome.
Wong CK, Lam CW, Wu AK, Ip WK, Lee NL, Chan IH, Lit LC, Hui DS, Chan MH, Chung SS, Sung JJ.
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused by a novel coronavirus, but its immunopathological mechanisms have not yet been fully elucidated. We investigated changes in plasma T helper (Th) cell cytokines, inflammatory cytokines and chemokines in 20 patients diagnosed with SARS. Cytokine profile of SARS patients showed marked elevation of Th1 cytokine interferon (IFN) -gamma, inflammatory cytokines interleukin (IL) -1, IL-6 and IL-12 for at least 2 weeks after disease onset, but there was no significant elevation of inflammatory cytokine tumour necrosis factor (TNF) -alpha, anti-inflammatory cytokine IL-10, Th1 cytokine IL-2 and Th2 cytokine IL-4. The chemokine profile demonstrated significant elevation of neutrophil chemokine IL-8, monocyte chemoattractant protein-1 (MCP-1), and Th1 chemokine IFN-gamma-inducible protein-10 (IP-10). Corticosteroid reduced significantly IL-8, MCP-1 and IP-10 concentrations from 5 to 8 days after treatment (all P < 0.001). Together, the elevation of Th1 cytokine IFN-gamma, inflammatory cytokines IL-1, IL-6 and IL-12 and chemokines IL-8, MCP-1 and IP-10 confirmed the activation of Th1 cell-mediated immunity and hyperinnate inflammatory response in SARS through the accumulation of monocytes/macrophages and neutrophils.
J Infect Chemother. 2004 Feb;10 (1) :1-7. Related Articles, Links
Current concepts in SARS treatment.
Fujii T, Nakamura T, Iwamoto A.
Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan. tmks@ims.u-tokyo.ac.jp
The outbreak of severe acute respiratory syndrome (SARS) has drawn enormous attention and caused fear worldwide since early 2003. The disease appears to be under control now; however, the possible return of SARS must be emphasized. Although many clinical experiments have been reported, the treatment of SARS is largely anecdotal, and so far no treatment consensus has been reached. We summarize 14 clinical reports and attempt to assess the effectiveness of various treatment regimens. A combination treatment of steroids and ribavirin was widely used empirically from the outset of the epidemic. In general, the use of steroids for SARS seemed beneficial, but the optimal timing, dosage, and duration of treatment have not yet been determined. On the other hand, ribavirin administration apparently reduced neither the rate of intratracheal intubation nor that of mortality. Moreover, significant toxicity, such as hemolytic anemia, has been attributed to ribavirin. A few preliminary trials and in vitro data suggest the possibility of treating SARS with interferon. Other agents, including the HIV protease inhibitor glycyrrhizin and convalescent plasma, remain to be evaluated.
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Bangkok Women : Meet Beautiful Thai Girls
Posted on: 12:51 pm on April 24, 2004
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909 living
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SARS is coming back and it is going to be a seasonal illness such as the flu or cold. It just has a higher death ratio.
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Bangkok Girls : Meet Attractive Thai Girls
Posted on: 1:13 pm on April 30, 2004
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